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Selected Publications

Selected publications from the Microverse investigators.

2020

Seelbinder B, Chen J, Brunke S, Vazquez-Uribe R, Santhaman R, Meyer AC, Senne de Oliveira Lino F, Chan KF, Loos D, Imamovic L, Tsang CC, Puikin Lam R, Sridhar S,  Kang K, Hube B, Woo PC, Sommer MOA, Panagiotou G (2020) Antibiotics create a shift from mutualism to competetion in human gut communities with a longer lasting impact on fungi than bacteria. Microbiome, doi: 10.1186/s40168-020-00899-6.
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Azemtsop Matanfack G, Taubert M, Guo S, Houhou R, Bocklitz T, Küsel K, Popp J (2020) Influence of  carbon sources on quantification of deuterium incorporation in heterotrophic bacteria: a raman-stable isotope labeling approach. Analytical Chemistry, doi: 10.1021/acs.analchem.0c02443.
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Hoyos M, Huber M, Förstner KU, Papenfort K (2020) Gene autoregulation by 3' UTR-derived bacterial small RNAs. eLife, doi: 10.7554/eLife.58836.
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Krespach MKC, García-Altares M, Flak M, Schoeler H, Scherlach K, Netzker T, Schmalzl A, Mattern DJ, Schroeckh V, Komor A, Mittag M, Hertweck C, Brakhage AA (2020) Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulas protects algal cells from bacteria. ISME, doi: 10.1038/s41396-020-0731-2.
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Schmidt F, Thywißen A, Röcker M, Cunha C, Cseresnyés Z, Schmidt H, Galiani S, Gräler MH, Chamilos G, Lacerda JF, Campos AJ, Eggeling C, Figge MT, Heinekamp T, Filler SG, Carvalho A, Brakhage AA (2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Reports, doi: 10.1016/j.celrep.2020.108017.
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Kohn T, Rast P, Kallschuer N, Wiegand S, Boedeker C, Jetten MSM, Jeske O, Vollmers J, Kaster AK, Rohde M, Jogler M, Jogler C (2020) The microbiome of Posidonia oceania seagrass leaves can be dominated by planctomycetes. Front Microbiol, doi: 10.3389/fmicb.2020.01458.
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Gao C, Fernandez VI, Lee KS, Fenizia S, Pohnert G, Seymour JR, Raina JB, Stocker R (2020) Single-cell bacterial transcription measurements reveal the importance of dimethylsulfoniopropionate (DMSP) hotspots in ocean sulfur cycling. Nat Commun, doi: 10.1038/s41467-020-15693-z.
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Huber M, Fröhlich KS, Radmer J, Papenfort K (2020) Switching fatty acid metabolism by an RNA-controlled feed forward loop. PNAS, doi: 10.1073/pnas.1920753117.
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Heshiki Y, Vazquez-Uribe R, Li Ji, Ni Y, Quainoo S, Imamovic L, Li Ju, Sørensen M, Chow BKC, Weiss GJ, Xu A, Sommer MOA, Panagiotou G (2020) Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome, doi: 10.1186/s40168-020-00811-2.
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Yan L, Herrmann M, Kampe B, Lehmann R, Totsche KU, Küsel K (2020) Environmental selection shapes the formation of near-surface groundwater microbiomes. Water Res, doi: 10.1016/j.watres.2019.115341.
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Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS (2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication, doi: 10.1088/1758-5090/ab7073.
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Niehs SP, Dose B, Richter S, Pidot SJ, Dahse HM, Stinear TP, Hertweck C (2020) Mining symbionts of a spider-transmitted fungus illuminates unchartered biosynthetic pathways to cytotoxic benzolactones. Angew Chem Int Ed Engl, doi: 10.1002/anie.201916007.
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Stroe MC, Netzker T, Scherlach K, Krüger T, Hertweck C, Valiante V, Brakhage AA (2020) Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. eLife, doi: 10.7554/eLife.52541.
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Mukherji R, Zhang S, Chowdhury S, Stallforth P (2020) Chimeric LuxR transcription factors rewire natural product regulation. Angew Chem Int Ed, doi: 10.1002/anie.201914449.
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2019

Trottmann F, Franke J, Richter I, Ishida K, Cyrulies M, Dahse HM, Regestein L, Hertweck C (2019) Cyclopropanol warhead in malleicyprol confers virulence of human- and animal-pathogenic Burkholderia species. Angew Chem Int Ed 58: 14129-14133, doi: 10.1002/anie.201907324.
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Vallet M, Baumeister TUH, Kaftan F, Grabe V, Buaya A, Thines M, Svatoš A, Pohnert G (2019) The oomycete Lagenisma coscinodisci hijacks host alkaloid synthesis during infection of a marine diatom. Nat Commun 10: 4938, doi: 10.1038/s41467-019-12908-w.
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Wondraczek L, Pohnert G, Schacher FH, Köhler A, Gottschaldt M, Schubert US, Küsel K, Brakhage AA (2019) Artificial Microbial Arenas: Materials for Observing and Manipulating Microbial Consortia. Adv Mater: 1900284, doi: 10.1002/adma.201900284.
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Bacher P, Hohnstein T, Beerbaum E, Röcker M, Kaufmann S, Brandt C, Röhmel J, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Heine G, Worm M, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Brunke S, Hube B, Blango M, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6): 1340-1355.e15.
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2018

Thume K, Gebser B, Chen L, Meyer N, Kieber DJ, Pohnert G (2018) Dimethylsulfoxonium propionate – a metabolite extending the marine organosulfur cycle. Nature 563: 412-5.

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Glória Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latgé JP, Brown GD (2018) Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature 555: 382-6
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Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C (2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14: 841-3.
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Vågene ÅJ, Herbig A, Campana MG, Robles García NM,  Warinner C, Sabin S, Spyrou MA, Andrades Valtueña A, Huson D, Tuross N, Bos KI, Krause J (2018) Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico. Nat Ecol Evol 2: 520-8.
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Dunbar KL, Büttner H, Molloy EM, Dell M, Kumpfmüller J, Hertweck C (2018) Genome editing reveals novel thiotemplated assembly of polythioamide antibiotics in anaerobic bacteria. Angew Chem Int Ed 57: 14080-4.
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Englert C, Nischang I, Bader C, Borchers P, Alex J, Pröhl M, Hentschel M, Hartlieb M, Träger A, Pohnert G, Schubert S, Gottschaldt M, Schubert US (2018) Photocontrolled release of chemicals from nano- and microparticle containers. Angew Chem Int Ed 57: 2479-82.
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Santos AM, Ponjavic A, Fritzsche M, Fernandes RA, de la Serna JB, Wilcock MJ, Schneider F, Urbancic I, McColl J, Anzilotti C, Ganzinger KA, Aßmann M, Depoil D, Cornall RJ, Dustin ML, Klenerman D, Davis SJ, Eggeling C, Lee SF (2018) Capturing resting T cells: the perils of PLL. Nat Immunol 19: 203-5.
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2017

Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schauble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2017) Metabolic adaptation establishes disease tolerance to sepsis. Cell 169: 1263-75.
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Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig E, Eggeling C (2017) Self-organizing actin patterns shape membrane architecture but not cell mechanics. Nat Commun 8: 14347.
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Aiyar P, Schaeme D, García-Altares M, Carrasco Flores D, Dathe H, Hertweck CH, Sasso S, Mittag G (2017) Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nat Commun 8: 1756.
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Sollapur R, Kartashov D, Zürch M, Hoffmann A, Grigorova T, Sauer G, Hartung A, Schwuchow A, Bierlich J, Kobelke J, Chemnitz M, Schmidt MA, Spielmann C (2017) Resonance-enhanced multi-octave supercontinuum generation in antiresonant hollow-core fibers. Light Sci Appl 6: e17124.
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2016

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532: 64-8.
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Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Beereswill S, Heimesaat M, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira-Briza F, Wallner M, Worm M, Scheffold A (2016) Regulatory T cell specificity directs tolerance versus allergy against aeroantigens in humans. Cell 167: 1067-78.
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Beulig F, Urich T, Nowak M, Trumbore SE, Gleixner G, Gilfillan GD, Fjelland KE, Küsel K (2016) Altered carbon turnover processes and microbiomes in soils under long-term extremely high CO2 exposure. Nat Microbiol 1: 15025.
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Winter S, Jahn K, Wehner S, Kuchenbecker L, Marz M, Stoye J, Böcker S (2016) Finding approximate gene clusters with Gecko 3. Nucleic Acids Res 44: 9600-10.
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Petroutsos D, Tokutsu R, Maruyama S, Flori S, Greiner A, Magneschi L, Cusant L, Kottke T, Mittag M,  Egemann P, Finazzi G, Minagawa J (2016) A blue-light photoreceptor mediates the feedback regulation of photosynthesis. Nature 537: 563-6.
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Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein PC, Bandeira N, Wang M, Schulze T, Salek RM, Steinbeck C, Nainala VC, Mistrik R, Nishioka T, Fiehn O (2016) SPLASH, a hashed identifier for mass spectra. Nat Biotechnol 34: 1099-101.
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2015

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350: 670-4.
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Santhanam R, Luu VT, Weinhold A, Goldberg J, Oh Y, Baldwin IT (2015) Native root-associated bacteria rescue a plant from a sudden-wilt disease that emerged during continuous cropping. PNAS 112: E5013-20
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Berry D, Mader E, Lee TK, Woebken D, Palatinszky M, Schmid MC, Hanson BT, Wang Y, Zhu D, Schintlmeister A, Wagner M, Shterzer N, Mizrahi I, Rauch I, Decker T, Bocklitz T, Popp J, Gibson CM, Fowler PW, Huang WE (2015) Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells. PNAS 112: E194-203.
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Lange M, Eisenhauer N, Sierra CA, Bessler H, Engels C, Griffiths RI, Mellado-Vázquez PG, Malik AA, Roy J, Scheu S, Steinbeiss S, Thomson BC, Trumbore SE, Gleixner (2015) Plant diversity increases soil microbial activity and soil carbon storage. Nat Commun 6: 6707.
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2014

Wicker K, Heintzmann R (2014) Resolving a misconception about structured illumination. Nat Photonics 8: 342-4.

Bos KI, Harkins KM, Herbig A, Coscolla M, Weber N, Comas I, Forrest SA, Bryant JM, Harris SR, Schuenemann VJ, Campbell TJ, Majander K, Wilbur AK, Guichon RA, Wolfe Steadman DL, Cook DC, Niemann S, Behr MA, Zumarraga M, Bastida R, Huson D, Nieselt K, Young D, Parkhill J, Buikstra JE, Gagneux S, Stone AC, Krause J (2014) Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. Nature 514: 494-7.
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Press AT, Traeger A, Pietsch C, Mosig A, Wagner M, Jbeily N, Koch N, Gottschaldt M, Ermolayev V, Beziere N, Popp J, Kessels M, Qualmann B, Clemens MG, Ntziachristos V, Schubert US, Bauer M (2014) Cell type-specific delivery of short interfering RNAs by dyefunctionalised theranostic nanoparticles. Nat Commun 5: 5565.
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Hädrich S, Klenke A, Rothhardt J, Krebs M, Hoffmann A, Pronin O, Pervak V, Limpert J, Tünnermann A (2014). High photon flux table-top coherent extreme-ultraviolet source. Nat Photonics 8: 779-83.

Warinner C, Rodrigues JFM, Vyas R, Trachsel C, Shved N, Grossmann J, Radini A, Hancock Y, Tito RY, Fiddyment S, Speller C, Hendy J, Charlton S, Luder HU, Salazar-García DC, Eppler E, Seiler R, Hansen L, Samaniego Castruita JA, Barkow-Oesterreicher S, Teoh KY, Kelstrup C, Olsen JV, Nanni P, Kawai T, Willerslev E, von Mering C, Lewis Jr. CM, Collins MJ, Gilbert MTP, Rühli F, Cappellini E (2014) Pathogens and host immunity in the ancient human oral cavity. Nat Genet 46: 336-44.
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2013

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C (2013) Vinylogous chain branching catalyzed by a dedicated polyketide synthase module. Nature 502: 124-8.
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Schuenemann VJ, Singh P, Mendum TA, Krause-Kyora B, Jäger G, Bos KI, Herbig A, Economou C, Benjak A, Busso P, Nebel A, Boldsen JL, Kjellström A, Wu H, Stewart GR, Taylor GM, Bauer P, Lee OY, Wu HH, Minnikin DE, Besra GS, Tucker K, Roffey S, Sow SO, Cole ST, Nieselt K, Krause J (2013) Genome-wide comparison of medieval and modern Mycobacterium leprae. Science 341: 179-83.
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Gröschel AH, Walther A, Löbling TI, Schacher FH, Schmalz H, Müller AHE (2013) Guided hierarchical co-assembly of soft patchy nanoparticles. Nature 503: 247-51.
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Wondraczek L, Batentschuk M, Schmidt MA, Borchardt R, Scheiner S, Seemann B, Schweizer P, Brabec CJ (2013) Solar spectral conversion for improving the photosynthetic activity in algae reactors. Nat Commun 4: 2047.
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Previous

Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, Ramulu Elluru S, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP (2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460: 1117-21.
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